ISTM

Having completed a BSc (Hons) in Biochemistry at the University College of Wales, Aberystwyth Alison began her research career working at The North East Wales Institute on Deeside working in a group producing monoclonal antibodies for use in Muscular Dystrophy research. She then moved to work in the Quality Control Department of Evans Medical Ltd, Liverpool and then Porton Speywood Ltd, Wrexham.

In 2002 she moved into rheumatology research with Keele University at the RJAH Orthopaedic Hospital in Oswestry. In 2006 she began a part-time PhD in Biomedical Engineering with Keele University. She investigated the role of chemokine receptors on leukocytes in rheumatoid arthritis, completing this in 2011. In 2012 Alison began working as a Postdoctoral Research Associate in the Institute for Science & Technology in Medicine, Keele University based at the RJAH Hospital, continuing her PhD work looking at chemokine receptors in inflammation in inflammatory arthritis.

Biology and pathology of inflammation in rheumatoid and psoriatic arthritis

Chemokines, chemokine receptors and leukocyte biology

Man N, Cartwright AJ, Andrews KM, Morris GE. (1989). Treatment of human muscle creatine kinase with glutaraldehyde preferentially increases the immunogenicity of the native conformation and permits production of high-affinity monoclonal antibodies which recognize two distinct surface epitopes. Journal of Immunological Methods 125 (1-2):251-259.

Nguyen thi Man, Cartwright AJ, Morris GE, Love DR, Bloomfield JF, Davies KE. (1990). Monoclonal antibodies against defined regions of the muscular dystrophy protein, dystrophin. FEBS Letters 262 (2):237-240.

Morris GE, Cartwright AJ. (1990). Monoclonal antibody studies suggest a catalytic site at the interface between domains in creatine kinase. Biochimica et Biophysica Acta. 1039(3):318-322.

Nguyen TM, Ellis JM, Ginjaar IB, van Paassen MM, van Ommen GJ, Moorman AF, Cartwright AJ, Morris GE. (1990). Monoclonal antibody evidence for structural similarities between the central rod regions of actinin and dystrophin. FEBS Letters 272 (1-2):109-112.

Nguyen thi Man, Cartwright AJ, Osborne M, Morris GE. (1991). Structural changes in the C-terminal region of human brain creatine kinase studied with monoclonal antibodies. Biochimica et Biophysica Acta 1076 (2):245-251.

Goodstone NJ, Cartwright A, Ashton B. (2004). Effects of high molecular weight hyaluronan on chondrocytes cultured within a resorbable gelatin sponge. Tissue Engineering 10 (3-4):621-631.

Patterson AM, Cartwright A, DavidG, Fitzgerald O, Bresnihan B, Ashton BA, Middleton J. (2008). Differential expression of syndecans and glypicans in chronically inflamed synovium. Annals of Rheumatic Diseases 67 (5) 592-601. (IF 6.9)

Schmutz C, Cartwright A,Haworth O, Loreau E, FilerA, SalmonM, Buckley C, Middleton J (2008). Monocyte/macrophage expression of CCR9 in rheumatoid arthritis (Abstract). Rheumatology; 47 Suppl 2: 62.

Schmutz C, Cartwright A, Williams H, Haworth O, Williams JH, Filer A, Salmon M, Buckley CD, Middleton J. (2010) Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation. Arthritis, Research and Therapy 12(4):R161.

Cartwright A, Schmutz C, Askari A and Middleton J. (2010). Expression of GPR15/BOB on monocytes and neutrophils in peripheral blood and on monocytes/macrophages in synovial tissue and synovial fluid of rheumatoid arthritis patients (Abstract) Rheumatology, 49 Suppl 1: i43-i45.

Cartwright A, Schmutz C, Askari A  and Middleton.J. (2011). Up-regulation of orphan chemokine receptor GPR15/BOB on leukocytes in rheumatoid arthritis hunting the ligand (Abstract).   Microcirculation, 18, (5), 4XX.

Collaborators:

Prof Jim Middleton
Faculty of Medicine and Dentistry
School of Oral and Dental Sciences,
University of Bristol

Dr Ayman Askari
Consultant Rheumatologist
RJAH Orthopaedic Hospital
Oswestry

Dr Atheer Al-Ansari
Consultant Rheumatologist
Hollinswood Rheumatology Centre / RJAH Orthopaedic Hospital,Oswestry & PRHHospital
Telford

Dr Mohammed  Al Abadie
Consultant Dermatologist
New Cross Hospital
Wolverhampton