Research Institutes

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Neuroscience & Human Metabolism theme:

The Neuroscience and Human Metabolism theme excels in several related basic, translational and clinical areas and applies state-of-the art approaches in the study of normal processes and disease mechanisms. There is basic research into neuroanatomy, cell physiology and pathology, the causes and management of heart disease and other metabolic disorders, development of new stem cell and other therapies for treatment of human disorders in the laboratory, and our research culminates in clinical trials and treatments in neurological and cardiovascular disease. Our work is based on multidisciplinary approaches to discover and treat the causes of disease and includes a wide range of technological approaches such as single cell and systems physiology, nanoscale devices and nanoparticles, confocal and electron microscopy, functional imaging and genetic studies.

In basic neuroscience, we conduct research into the functioning of the auditory system at the organ, cellular and molecular level, the physiology of retinal neurones, and plasticity in cortical processing in the somatosensory system. In human metabolism we investigate cellular mechanisms of atherogenesis, and the role of trace elements and antioxidants in disease.

In potentially translational neuroscience, we are performing research into stem cell therapy to promote neural regeneration and to treat diseases of the basal ganglia such as Parkinson’s disease. We are also investigating possible regenerative/stem cell approaches to prevention of hearing loss.

ISTM_Harpal_at_cabinet_200x233 In clinical neuroscience and human metabolism we are researching into multiple sclerosis (MS) and the range of neuropsychological deficits following stroke, including clinical trials in the treatment of both. We study dietary management of coronary risk, clinical management of dyslipidaemia and insulin resistance. We also research into polymorphic genes and how they interact with environmental factors such as ultraviolet radiation to influence susceptibility and outcome in MS, basal cell carcinoma and prostate cancer.

Associated with the theme, are other members of the institute that interact to enhance the cross-talk between different thematic research groups. These areas include regenerative medicine in spinal cord repair, the neural control of breathing, and nanomagnetic technology in cell and tissue engineering and tumour targeting,

NHM Theme Leader: Dr David Furness
NHM Clinical co-lead: Prof Clive Hawkins

For postgraduate research opportunities please go to the Prospective Student page.