Clinical & Diagnostic Science theme

The Clinical and Diagnostic Research theme in ISTM exploits state of the art basic science and health service research methodologies to answer important, clinically driven research questions.

Our basic science expertise includes genetics and epigenetics, structural biology, cell biology, including apoptosis and the control of cell growth and a wide range of analytical techniques such as proteomics, electromagnetic imaging and selected ion flow tube mass spectrometry (SIFT-MS).

The clinical areas to which these translational approaches are applied include in utero fetal wellbeing, the development of novel anti-cancer drugs, e.g. treatment of ovarian cancer, leukaemia and breast cancer and a wide range of chronic diseases with underlying common mechanisms of tissue injury such as diabetes, renal failure, coronary heart disease, lung disease, rheumatoid arthritis and childhood asthma.

General_ISTM_lab_b_288x229 Innovative approaches to improved management of these conditions through diagnosis and therapeutic monitoring of these frequently multimorbid patients include epigenetic screening, identification of useful prognostic biomarkers, imaging and breath analysis. Evaluation of best care includes health service research into perineal trauma, menstrual disorders, medicines for children, dialysis modality decision aids and the best use of the pathology service in patient management. 

CDS Theme Leader: Prof Gwyn Williams
CDS Clinical co-lead: Prof Simon Davies

For postgraduate research opportunities please go to the Prospective Student page.

ISTM Members in this theme

Download the ISTM membership list

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News features

FlourochemM_Dr_Alan_Richardson_Elizabeth_Robinson_90x90   ISTM invests in the latest imaging equipment Posted on 23 May 2012 Fifteen members of the Research Institute now have access to the latest imaging equipment for their experiments on two sites Nature_Reviews_Endocrinology_image_90x90   Nature article for Epigenomics students Posted on 30 April 2012 Final year PhD students Kiren Yacqub-Usman and Cuong Duong, were delighted to learn that their submission to Nature Reviews Endocrinology had been accepted.   Vietnam university appointment for Prof Bill Farrell Posted on 30 March 2012 Professor Bill Farrell has been appointed as an Honorary Visiting Professor at the TUAF University in Vietnam keele710   USA Journal Club recognition for Keele research Posted on 16 March 2012 Four members of ISTM are authors on a research paper which has been selected as a feature article by the American Clinical Chemistry Journal Club programme. Bill_Farrell_and_equipment_90x90   Epigenetic study makes TV and radio headlines Posted on 02 February 2011 Groundbreaking work led by the Epigenomics team in ISTM gained wide media coverage at the start of 2011. ISTM_Safeceps_90x90 suit news page   Spin out company wins design award Posted on 30 May 2010 Medical device company PRO Medical Innovations – a spin-out company from Keele – has been awarded "red dot recognition" for the design of Safeceps obstetric forceps, a modern-day plastic adaptation of the traditional birthing tool.