Clinical and Diagnostic Science - Keele University

Clinical & Diagnostic Science theme

The Clinical and Diagnostic Research theme in ISTM exploits state of the art basic science and health service research methodologies to answer important, clinically driven research questions.

Our basic science expertise includes genetics and epigenetics, structural biology, cell biology, including apoptosis and the control of cell growth and a wide range of analytical techniques such as proteomics, electromagnetic imaging and selected ion flow tube mass spectrometry (SIFT-MS).

The clinical areas to which these translational approaches are applied include in utero fetal wellbeing, the development of novel anti-cancer drugs, e.g. treatment of ovarian cancer, leukaemia and breast cancer and a wide range of chronic diseases with underlying common mechanisms of tissue injury such as diabetes, renal failure, coronary heart disease, lung disease, rheumatoid arthritis and childhood asthma.

General_ISTM_lab_b_288x229 Innovative approaches to improved management of these conditions through diagnosis and therapeutic monitoring of these frequently multimorbid patients include epigenetic screening, identification of useful prognostic biomarkers, imaging and breath analysis. Evaluation of best care includes health service research into perineal trauma, menstrual disorders, medicines for children, dialysis modality decision aids and the best use of the pathology service in patient management. 

CDS Theme Leader: Prof Gwyn Williams
CDS Clinical co-lead: Prof Simon Davies

For postgraduate research opportunities please go to the Prospective Student page.

ISTM Members in this theme

Download the ISTM membership list

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A list of ISTM members grouped by theme: PDF document that prints as one A4 page.

News features

GC-MS_and_TD_capability_with_Dr_Wen-Wu_Li_GHRC_Nov2012_IMG_3002_90x90   New Analytical Technique for ISTM Laboratories Posted on 16 November 2012 Keele has invested in the latest Gas Chromatograph Mass Spectrometry (GC-MS) equipment, coupled to Thermal Desorption (TD) capability. Claire_Rushton_90x90   New Research Fellowship to study Co-morbidity in heart failure patients Posted on 28 September 2012 A 3 year Doctoral Research Fellowship from the NIHR has been awarded to Claire Rushton, Lecturer in Nursing & Midwifery Ed_Chadwick_AUweb2012_90x90   Lecture on Biomedical Engineering by Dr Ed Chadwick Posted on 23 November 2012 Dr Ed Chadwick gave a first lecture to colleagues to introduce his research at the Guy Hilton Research Centre on 23 November. Catriona_Kelly_and_Alan_Harper_2012_IMG_2140_90x90   New Spectrophotometer benefits two lecturers’ research Posted on 29 June 2012 The purchase of a monochromator-based fluorescence spectrophotometer system in April has enabled two Keele lecturers to start a new series of experiments. FlourochemM_Dr_Alan_Richardson_Elizabeth_Robinson_90x90   ISTM invests in the latest imaging equipment Posted on 23 May 2012 Fifteen members of the Research Institute now have access to the latest imaging equipment for their experiments on two sites Nature_Reviews_Endocrinology_image_90x90   Nature article for Epigenomics students Posted on 30 April 2012 Final year PhD students Kiren Yacqub-Usman and Cuong Duong, were delighted to learn that their submission to Nature Reviews Endocrinology had been accepted.   Vietnam university appointment for Prof Bill Farrell Posted on 30 March 2012 Professor Bill Farrell has been appointed as an Honorary Visiting Professor at the TUAF University in Vietnam keele710   USA Journal Club recognition for Keele research Posted on 16 March 2012 Four members of ISTM are authors on a research paper which has been selected as a feature article by the American Clinical Chemistry Journal Club programme.