Dr S Glazewski 

Title	Lecturer in Neuroscience
Phone	+44 (0)1782 733029	Internal 33029
Fax	+44 (0)1782 733516
Email	s.glazewski@cns.keele.ac.uk
Room	Huxley Building : 103b
Roles	Second Year Tutor for Neuroscience Study Abroad Tutor for Neuroscience Honorary Research Fellow – Cardiff School of Biosciences, Cardiff University, U.K. (Feb. 1st. 2002-present). Visiting Research Scholar – Department of Biological Sciences, Carnegie-Melon University, Pittsburgh, USA (June 15th 2004 – present). Member of the Advisory Board of the Nencki Institute PhD Programme
Contact	Try my office or email me

I have been at Keele since 2002. My first degree (Msc), in Molecular Biology from the University of Warsaw was followed by the PhD in Neuroscience and habilitation in Neurobiology from the Nencki Institute, Warsaw. I was working in several scientific institutions in Poland before departing to the U.S (Georgetown University, Washington, D.C.; University of Minnesota, Minneapolis and Washington University, St. Louis) before coming to the UK (Cardiff University).

Research and Scholarship

A great deal of progress has been made in our understanding of brain function, in recent years, but we still do not know precisely how this organ acquires, stores and recalls information. A common assumption is, that it is done somehow via changes in synaptic weights and connectivity between neurons (plastic changes). Studying changes in neuronal transmission and connectivity in intact animals during learning it is quite a big task as we usually do not know, where these changes take a place, nor what they mean and whether they are specifically related to learning and memory or not. Those are the main reasons for studying mechanisms of plastic changes using model systems. For example, the barrel cortex of rodents, where vibrissae are represented. The unique anatomical organisation of this cortical area enables quantitative and very accurate measurement of plasticity induced by change in experience. For instance, due to changing vibrissae complement for some period of time. My research aims to understand how experience induces neuronal plasticity in the neocortex and how this plasticity is maintained; namely, to discover the physiological mechanisms of synaptic potentiation and depression, how these changes are stabilised during development and the molecules involved. Recently, I am also interested in the mechanisms underlying simple forms of learning that may be induced in the barrel cortex with use of whiskers, synaptic changes driven by circadian rhythms and the consequences of demyelination.

Recent Publications

Wright N., Glazewski S. Hardingham N. Phillips K., Pervolaraki E.and Fox K Laminar analysis of the role played by GluR1 in experience-dependent and synaptic depression of sensory responses in barrel cortex” submitted to Nature Neroscience.

Jasinska M., Siucinska E., Furness D.N., Pyza E.,KossutM. and Glazewski. Rapid, learning-induced synaptogenesis in murine barrel field. in preparation

Nowicka D., Soulsby S., Karetko M., Skangiel-Kramska J.and Glazewski S. Univibrissa rearing, but not chessboard deprivation up-regulates parvalbumin containing neurons in a granular layer of the barrel cortex. in preparation

Glazewski S., Benedetti B.L. and Barth A. (2007) Ipsilateral whiskers suppress experience-dependent plasticity in the barrel cortex. J. Neurosci., 27: 3019-3920.

Jasinska M., Siucinska E., Glazewski S., Pyza E. and KossutM. (2006) Characterization and plasticity of the double synapse spines in the barrel cortex of the mouse. Acta Neurobiologiae Experimetalis, 66: 99-104.

Teaching

Life Sciences

Second Year tutor
LSC-10020 – Introduction to Neuroscience
LSC-10025  - Introduction to Human Physiology
LSC-10026 - Cell and Molecular Neuroscience
LSC-20005 - Endocrinology and Signalling
PHA-20004 - Principles of Pharmacology
LSC-20027 - From Neurone to Brain (module manager)
LSC-20023 - Development and Evolution of  Nervous System
LSC-30021 – Research Project in Neuroscience (module manager)
LSC30022- Non-Experimental Project in Neuroscience (module manager)
LSC-30023 - Final Year Dissertation in Neuroscience (module manager)

Pharmacy

PHA-20004 - Principles of Pharmacology

MedicalSchool

PBL tutor
Lecturer
Neuroanatomy practicals

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