Dr Tess Phillips

Title: Lecturer
Phone: (+44) 01782 7 33038
Email:
Location: Lennard-Jones 0.21
Role:
Contacting me: In my office (Weds & Thurs) or by e-mail
Phillips_Tess

I came to Keele in 2008 as a PDRA working with Prof. Pat Bailey and was appointed to Research Fellow in 2011 and Lecturer in 2013. 

I graduated from the University of Cambridge in 1999 with a Masters degree in Natural Sciences, specialising in Chemistry.  I stayed on in Cambridge to complete a PhD under the supervision of Prof. Andrew Holmes, investigating how palladium-catalysed reactions can be conducted using environmentally benign carbon dioxide as an alternative to traditional organic solvents. 

After completing my PhD in 2003, I spent two and a half years as a medicinal chemist at the Cambridge based biotech company Astex Technology (which became Astex Therapeutics in 2005).  During this time I worked on a number of oncology drug discovery projects. 

I then moved back into academia, joining The University of Manchester in November 2005, to take up a position as a postdoctoral research associate in Prof. Pat Bailey’s group working on the total synthesis of indole alkaloid natural products.  

My research interests are synthetic organic chemistry, medicinal and natural product chemistry and drug discovery.

See our Research Group's website for more information.

Selected Publications

  • Bailey PD, Beard MA, Cresswell M, Dang HPT, Pathak RB, Phillips TR, Price RA. 2013. Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids. TETRAHEDRON LETTERS, vol. 54(13), 1726-1729. link> doi>
  • Horrocks P, Fallon S, Denman L, Devine O, Duffy LJ, Harper A, Meredith EL, Hasenkamp S, Sidaway A, Monnery D, Phillips TR, Allin SM. 2012. Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads. Bioorg Med Chem Lett, vol. 22(4), 1770-1773. link> doi> full text>
  • Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith D-M, Trewartha G, Vinkovic M, Williams B, Woolford AJ-A. 2010. Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1, 3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, {5956-5969}. doi>
  • Bailey PD, Beard MA, Phillips TR. 2009. Unexpected cis selectivity in the Pictet-Spengler reaction. TETRAHEDRON LETTERS, vol. 50(26), 3645-3647. link> doi>
  • Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O Brien MA, O Reilly M, Reule M, Saxty G, Seavers LCA, Smith D-M, Squires MS, Trewartha G, Walker MT, Woolford AJ-A. 2008. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, {4986-4999}. doi>

Full Publications List show

Journal Articles

  • Bailey PD, Beard MA, Cresswell M, Dang HPT, Pathak RB, Phillips TR, Price RA. 2013. Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids. TETRAHEDRON LETTERS, vol. 54(13), 1726-1729. link> doi>
  • Horrocks P, Fallon S, Denman L, Devine O, Duffy LJ, Harper A, Meredith EL, Hasenkamp S, Sidaway A, Monnery D, Phillips TR, Allin SM. 2012. Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads. Bioorg Med Chem Lett, vol. 22(4), 1770-1773. link> doi> full text>
  • Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith D-M, Trewartha G, Vinkovic M, Williams B, Woolford AJ-A. 2010. Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1, 3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, {5956-5969}. doi>
  • Murray CW, Carr MG, Callaghan O, Chessari G, Congreve M, Cowan S, Coyle JE, Downham R, Figueroa E, Frederickson M, Graham B, McMenamin R, O Brien MA, Patel S, Phillips TR, Williams G, Woodhead AJ, Woolford AJ-A. 2010. Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, {5942-5955}. doi>
  • Bailey PD, Beard MA, Phillips TR. 2009. Unexpected cis selectivity in the Pictet-Spengler reaction. TETRAHEDRON LETTERS, vol. 50(26), 3645-3647. link> doi>
  • Howard S, Berdini V, Boulstridge JA, Carr MG, Cross DM, Curry J, Devine LA, Early TR, Fazal L, Gill AL, Heathcote M, Maman S, Matthews JE, McMenamin RL, Navarro EF, O Brien MA, O Reilly M, Rees DC, Reule M, Tisi D, Williams G, Vinkovic M, Wyatt PG. 2009. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, {379-388}. doi>
  • Bailey PD, Beard MA, Dang HPT, Phillips TR, Price RA, Whittaker JH. 2008. Debenzylation using catalytic hydrogenolysis in trifluoroethanol, and the total synthesis of (-)-raumacline. Tetrahedron letters, vol. 49, 2150-2153.
  • Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O Brien MA, O Reilly M, Reule M, Saxty G, Seavers LCA, Smith D-M, Squires MS, Trewartha G, Walker MT, Woolford AJ-A. 2008. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, {4986-4999}. doi>
  • Smith CJ, Early TR, Holmes AB, Shute RE. 2004. Palladium catalysed cross-coupling reactions of silylamines. CHEMICAL COMMUNICATIONS, 1976-1977. doi>
  • Early TR, Gordon RS, Carroll MA, Holmes AB, Shute RE, McConvey IF. 2001. Palladium-catalysed cross-coupling reactions in supercritical carbon dioxide. CHEMICAL COMMUNICATIONS, 1966-1967. doi>

Chapters

  • Early TR, Holmes AB, Lee J-K, Quaranta E, Stamp LM. 2003. Homogeneous catalysis in supercritical carbon dioxide. In Carbon dioxide recovery and utilization. Aresta M (Ed.). Springer Netherlands.

Other

  • Holmes AB, Smith CJ, Tsang MW-S, Early TR, Shute RE. 2005. Amination of aromatic compounds using transition metal catalysts.
  • Holmes AB, Gordon RS, Early TR. 2003. Chemical reactions in compressed carbon dioxide using palladium catalysts.
  • Holmes AB, Ley SV, Gordon RS, Ramarao C, Early TR. 2003. Microencapsulated transition metal reagents for reactions in supercritical fluids.
  • Berdini V, Early TR, Brien MAO, Woodhead AJ, Wyatt PG. 2006. Pharmaceutical compounds such as substituted thiazole and isothiazole derivatives and their preparation, pharmaceutical compositions, formulations, and use in prophylaxis or treatment of disease states or conditions mediated by cyclin dependent kinase such as cancers, fungal infections or agricultural use.
  • Berdini V, Brien MAO, Carr MG, Early TR, Navarro EF, Gill AL, Trewartha G, Woolford AJ-A, Woodhead AJ, Wyatt PG. 2005. Preparation of 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators.
  • Wyatt PG, Berdini V, Gill AL, Trewartha G, Woodhead AJ, Navarro EF, Brien MAO, Phillips TR. 2006. Preparation of 4-amino-3-pyrazolecarboxamides as CDK2 kinase inhibitors.
  • Chessari G, Congreve MS, Navarro EF, Frederickson M, Murray C, Woolford AJ-A, Carr MG, Downham R, Brien MAO, Phillips TR, Woodhead AJ. 2006. Preparation of hydroxybenzamides as Hsp90 inhibitors.
  • Wyatt PG, Berdini V, Gill AL, Trewartha G, Woodhead AJ, Navarro EF, Brien MAO, Phillips TR. 2006. Preparation of pyrazole derivatives for use in pharmaceutical compositions for the inhibition of cyclin dependent kinases and glycogen synthase kinases.
  • Berdini V, Brien MAO, Carr MG, Early TR, Navarro EF, Gill AL, Howard S, Trewartha G, Woolford AJ-A, Woodhead AJ, Wyatt P. 2005. Preparation of pyrazoles as inhibitors of cyclin dependent kinases, glycogen synthase kinase-3 and Aurora kinase.
  • Berdini V, Brien MAO, Phillips TR, Wyatt PG. 2006. Preparation of thiazole and isothiazole derivatives that modulate the activity of cdk, gsk and aurora kinases.

CHE-00027: General and Organic Chemistry

CHE-00029: General and Organic Chemistry for Health

CHE-10043: Making Organic Molecules

CHE-20001: Organic Synthesis and Chirality

CHE-20005: Drug Design based on Biological Targets

EDU-10049: Organic Reactions

I am active in promoting the understanding of what molecules are through hands-on outreach activities.  I run the Molecules Network - a group of schools committed to molecules based science outreach in their communities. 

See the Make-it-Molecular website for more information.