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Chemistry

Professor Patrick Bailey

Title: Professor of Chemistry
Phone: (+44) 01782 7 34583
Email:
Location: Colin Reeves 37
Role: Dean of Faculty of Natural Sciences
Contacting me: By email, or through my PA (Janet Drewery) 01782 733269
Bailey_Pat

I came to Keele in January 2008, after a varied academic background.  I carried out my UG and PhD degrees in Chemistry at Oxford, and then took up a lectureship at York in 1983 (although I had originally intended to be a schoolteacher in 'Chemistry and Outdoor Pursuits').  I took up the Chair of Organic Chemistry at Heriot-Watt University (Edinburgh) in 1993, and then moved to Manchester in 2001 as Professor of Organic Chemistry, and then as the Dean for Teaching & Learning in Faculty of Engineering & Physical Sciences (overseeing 8000 students).  I've run a medium-sized research group (6-10 people) in medicinal/synthetic chemistry, but I've also been very involved in developing new teaching methods in universities (awarded National Teaching Fellowship in 2005), and in outreach activities to schools and the general public.

Bailey image My research has focused on four main themes:
1) Work on protein mechanisms, most recently on peptide transporters.
2) The synthesis of alkaloids (toxic natural products, that often have valuable pharmaceutical properties if used/developed in the right way), especially:

  • indole akaloids, including ones used to treat heart conditions;
  • piperidine alkaloids, particularly using Diels-Alder chemistry.

3) Studies on the synthesis and properties of ususual macrocycles.
My research has been recognized by a Yorkshire Cancer Research Campaign career development award (1986-91), the Zeneca Research Award for Organic Chemistry in 1994, and election to the Royal Society of Edinburgh (1999).

Two current projects are especially exciting; we're close to completing (we hope!) the first really efficient synthesis of an indole alkaloid called ajmaline, which is used to treat patients with irregular heartbeat, and has 9 adjacent chiral centres in its amazing 3D structure.  Secondly, we have been studying how to help the uptake of pharmaceutically important compounds that aren't orally absorbed; we now have a way of attaching such molecules to a special carrier, allowing them to be 'smuggled' into the bloodstream in tablet form.

More information is available on my research group's website.

Selected Publications

  • Foley DW, Rajamanickam J, Bailey PD, Meredith D. 2010. Bioavailability through PepT1: the role of computer modelling in intelligent drug design. Curr Comput Aided Drug Des, vol. 6(1), 68-78.
  • Mace OJ, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, Bronk JR, Kellett GL, Meredith D, Boyd R, Pieri M, Bailey PD, Pettcrew R, Foley D. 2009. An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol, vol. 587(Pt 1), 195-210. doi>
  • Bailey PD, Boa AN, Clayson J. 2009. Synthesis and reactions of alpha-fluoro-alpha-amino amides. TETRAHEDRON, vol. 65(8), 1724-1736. link> doi>
  • Foley D, Bailey P, Pieri M, Meredith D. 2009. Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1. Org Biomol Chem, vol. 7(6), 1064-1067. doi>
  • Foley D, Pieri M, Pettecrew R, Price R, Miles S, Lam HK, Bailey P, Meredith D. 2009. The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1. Org Biomol Chem, vol. 7(18), 3652-3656. doi>

Full Publications List show

Journal Articles

  • Foley DW, Rajamanickam J, Bailey PD, Meredith D. 2010. Bioavailability through PepT1: the role of computer modelling in intelligent drug design. Curr Comput Aided Drug Des, vol. 6(1), 68-78.
  • Mace OJ, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, Bronk JR, Kellett GL, Meredith D, Boyd R, Pieri M, Bailey PD, Pettcrew R, Foley D. 2009. An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol, vol. 587(Pt 1), 195-210. doi>
  • Bailey PD, Boa AN, Clayson J. 2009. Synthesis and reactions of alpha-fluoro-alpha-amino amides. TETRAHEDRON, vol. 65(8), 1724-1736. link> doi>
  • Foley D, Bailey P, Pieri M, Meredith D. 2009. Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1. Org Biomol Chem, vol. 7(6), 1064-1067. doi>
  • Foley D, Pieri M, Pettecrew R, Price R, Miles S, Lam HK, Bailey P, Meredith D. 2009. The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1. Org Biomol Chem, vol. 7(18), 3652-3656. doi>
  • Bailey PD, Beard MA, Phillips TR. 2009. Unexpected cis selectivity in the Pictet-Spengler reaction. TETRAHEDRON LETTERS, vol. 50(26), 3645-3647. link> doi>
  • Johnston KA, Allcock RW, Jiang Z, Collier ID, Blakli H, Rosair GM, Bailey PD, Morgan KM, Kohno Y, Adams DR. 2008. Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones. Org Biomol Chem, vol. 6(1), 175-186. doi>
  • Bailey PD, Beard MA, Dang HPT, Phillips TR, Price RA, Whittaker JH. 2008. Debenzylation using catalytic hydrogenolysis in trifluoroethanol, and the total synthesis of (-)-raumacline. TETRAHEDRON LETTERS, vol. 49(13), 2150-2153. link> doi>
  • Bailey PD, Sethi A, Pritchard RG. 2008. Macrocyclic sulfamides: synthesis, hybridization, and metal binding properties. TETRAHEDRON LETTERS, vol. 49(13), 2159-2162. link> doi>
  • Pieri M, Hall D, Price R, Bailey P, Meredith D. 2008. Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 40(4), 721-730. link> doi>
  • Ashnagar A, Bailey PD, Cochrane PJ, Mills TJ, Price RA. 2007. Unusual rearrangements and cyclizations involving polycyclic indolic systems. ARKIVOC, 161-171. link>
  • Bailey PD, Boyd CA, Collier ID, George JP, Kellett GL, Meredith D, Morgan KM, Pettecrew R, Price RA. 2006. Affinity prediction for substrates of the peptide transporter PepT1. Chem Commun (Camb), 323-325. doi>
  • Bailey PD, Boyd CA, Collier ID, George JG, Kellett GL, Meredith D, Morgan KM, Pettecrew R, Price RA, Pritchard RG. 2005. Conformational and spacial preferences for substrates of PepT1. Chem Commun (Camb), 5352-5354. doi>
  • Bailey PD, Boyd CA, Collier ID, Kellett GL, Meredith D, Morgan KM, Pettecrew R, Price RA. 2005. Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter. Org Biomol Chem, vol. 3(22), 4038-4039. doi>
  • Alberch L, Bailey PD, Clingan PD, Mills TJ, Price RA, Pritchard RG. 2004. The cis-specific Pictet-Spengler reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1887-1890. link> doi>
  • Bailey PD, Morgan KM, Smith DI, Vernon JM. 2003. Spiro cyclisations of N-acyliminium ions involving an aromatic pi-nucleophile. TETRAHEDRON, vol. 59(18), 3369-3378. link> doi>
  • Bailey PD, Clingan PD, Mills TJ, Price RA, Pritchard RG. 2003. Total synthesis of (-)-raumacline. Chem Commun (Camb), 2800-2801. doi>
  • Bailey PD, Smith PD, Pederson F, Clegg W, Rosair GM, Teat SJ. 2002. A high yielding route to substituted piperidines via the aza-Diels-Alder reaction. TETRAHEDRON LETTERS, vol. 43(6), 1067-1070. link> doi>
  • Shepherd EJ, Lister N, Affleck JA, Bronk JR, Kellett GL, Collier ID, Bailey PD, Boyd CA. 2002. Identification of a candidate membrane protein for the basolateral peptide transporter of rat small intestine. Biochem Biophys Res Commun, vol. 296(4), 918-922. doi>
  • Bailey PD, Smith PD, Morgan KM, Rosair GM. 2002. The use of the aza-Diels-Alder reaction in the synthesis of pinidine and other piperidine alkaloids. TETRAHEDRON LETTERS, vol. 43(6), 1071-1074. link> doi>
  • Bailey PD, Cochrane PJ, Lorenz K, Collier ID, Pearson DPJ, Rosair GM. 2001. A concise, efficient route to fumitremorgins. TETRAHEDRON LETTERS, vol. 42(1), 113-115. link> doi>
  • Bailey PD, Bannister N, Bernad M, Blanchard S, Boa AN. 2001. Synthesis of conformationally constrained amino acid and peptide derivatives. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 3245-3251. link> doi>
  • Bailey PD, Everitt SRL, Morgan KM, Brewster AG. 2001. The asymmetric synthesis and conformational analysis of new C-2-symmetric macrocycles derived from head-to-head linked alpha-amino acids and benzene or pyridine. TETRAHEDRON, vol. 57(7), 1379-1386. link> doi>
  • Hall A, Bailey PD, Rees DC, Rosair GM, Wightman RH. 2000. alpha-chloronitroso compounds derived from carbohydrate ketones: cycloadditions with cyclic dienes, a synthesis of (-)-physoperuvine and a formal synthesis of (+)-epibatidine. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 329-343. link> doi>
  • Bailey PD, McDonald IM, Rosair GM, Taylor D. 2000. An unusual oxidative rearrangement of azabicyclo[2.2.1]heptenes, providing a stereoselective route to 2 '- and 3 '-hydroxycyclopentylglycines. CHEMICAL COMMUNICATIONS, 2451-2452. link> doi>
  • Bailey PD, Boyd CAR, Bronk JR, Collier ID, Meredith D, Morgan KM, Temple CS. 2000. How to make drugs orally active: A substrate template for peptide transporter PepT1. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 39(3), 506-+. link>
  • Shepherd EJ, Affleck JA, Lister N, Bronk JR, Kellett GL, Boyd CAR, Collier LD, Bailey PD. 2000. Identification of a candidate peptide transporter in the basolateral membrane of rat intestinal mucosa. JOURNAL OF PHYSIOLOGY-LONDON, vol. 527, 35P. link>
  • Meredith D, Temple CS, Guha N, Sword CJ, Boyd CAR, Collier ID, Morgan KM, Bailey PD. 2000. Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1. EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 267(12), 3723-3728. link> doi>
  • Sword CJ, Constantinou AA, Collier ID, Bailey PD, Boyd CAR. 2000. Modified dipeptides inhibit substrate uptake into PepT1-expressing Xenopus oocytes. JOURNAL OF PHYSIOLOGY-LONDON, vol. 528P, 99P-100P. link>
  • Bailey PD, Morgan KM, Smith DI, Vernon JM. 2000. New asymmetric routes to ajmaline and suaveoline indole alkaloids. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 3566-3577. link> doi>
  • Bailey PD and Morgan KM. 2000. The total synthesis of (-)-suaveoline. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 3578-3583. link> doi>
  • Bailey PD, Boa AN, Baker SR, Clayson J, Murray EJ, Rosair GM. 1999. Piperazine-2,3,5-triones in the synthesis of constrained peptides. TETRAHEDRON LETTERS, vol. 40(42), 7557-7560. link> doi>
  • Bailey PD, Cochrane PJ, Irvine F, Morgan KM, Pearson DPJ, Veal KT. 1999. Swern oxidation of tryptamine derivatives. TETRAHEDRON LETTERS, vol. 40(24), 4593-4596. link> doi>
  • Bailey PD, Cochrane PJ, Forster AH, Morgan KM, Pearson DPJ. 1999. Synthesis of polycyclic indolic structures. TETRAHEDRON LETTERS, vol. 40(24), 4597-4600. link> doi>
  • Bailey PD, Morgan KM, Rosair GM, Thomas RL. 1999. Unusual biomimetic oxidations of indoles: synthesis of suaveoline and an alkaloid G analogue. TETRAHEDRON LETTERS, vol. 40(47), 8255-8259. link> doi>
  • Meredith D, Boyd CAR, Bronk JR, Bailey PD, Morgan KM, Collier ID, Temple CS. 1998. 4-aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1. JOURNAL OF PHYSIOLOGY-LONDON, vol. 512(3), 629-634. link> doi>
  • Hall A, Bailey PD, Rees DC, Wightman RH. 1998. Asymmetric cycloadditions of dienes to chloronitroso compounds derived from carbohydrate ketones: syntheses of (-)-physoperuvine and (+)-epibatidine. CHEMICAL COMMUNICATIONS, 2251-2252. link> doi>
  • Bailey PD, Millwood PA, Smith PD. 1998. Asymmetric routes to substituted piperidines. CHEMICAL COMMUNICATIONS, 633-640. link> doi>
  • Temple CS, Stewart AK, Meredith D, Lister NA, Morgan KM, Collier ID, Vaughan-Jones RD, Boyd CAR, Bailey PD, Bronk JR. 1998. Peptide mimics as substrates for the intestinal peptide transporter. JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273(1), 20-22. link> doi>
  • Temple CS, Collier ID, Bronk JR, Bailey PD, Boyd CAR. 1998. Structural requirements for non-peptide substrate binding to the epithelial proton-coupled oligopeptide transporter. JOURNAL OF PHYSIOLOGY-LONDON, vol. 511P, 26P-27P. link>
  • Bailey PD, Baker SR, Boa AN, Clayson J, Rosair GM. 1998. Synthesis of alpha-heterosubstituted glycine derivatives from dihaloethanamides. TETRAHEDRON LETTERS, vol. 39(42), 7755-7758. link> doi>
  • Bailey PD, Collier ID, Hollinshead SP, Moore MH, Morgan KM, Smith DI, Vernon JM. 1997. New asymmetric route to bridged indole alkaloids: Formal enantiospecific syntheses of (-)-suaveoline, (-)-raumacline and (-)-N-b-methylraumacline. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1209-1214. link> doi>
  • Lister N, Bailey PD, Collier ID, Boyd CA, Bronk JR. 1997. The influence of luminal pH on transport of neutral and charged dipeptides by rat small intestine, in vitro. Biochim Biophys Acta, vol. 1324(2), 245-250. doi>
  • Temple CS, Bailey PD, Bronk JR, Boyd CAR. 1996. A model for the kinetics of neutral and anionic dipeptide-proton cotransport by the apical membrane of rat kidney cortex. JOURNAL OF PHYSIOLOGY-LONDON, vol. 494(3), 795-808. link>
  • Bailey PD and Morgan KM. 1996. A total asymmetric synthesis of (-)-suaveoline. CHEMICAL COMMUNICATIONS, 1479-1480. link> doi>
  • Adams DR, Bailey PD, Collier ID, Heffernan JD, Stokes S. 1996. An efficient route to the alpha-methyl ester of L-glutamic acid, and its conversion into cis-5-hydroxy-L-pipecolic acid. CHEMICAL COMMUNICATIONS, 349-350. link> doi>
  • Temple CS, Bailey PD, Bronk JR, Boyd CAR. 1996. Membrane potential and pH dependence of neutral and charged dipeptide transport across rat renal cortex basolateral membrane vesicles. JOURNAL OF PHYSIOLOGY-LONDON, vol. 493P, P62-P63. link>
  • Bailey PD, Higgins SD, Ridyard CH, Roberts SM, Rosair GM, Whittaker RA, Willetts AJ. 1996. Selective biohydroxylation of 1-substituted adamantanes using Absidia cylindrospora (IMI 342950). CHEMICAL COMMUNICATIONS, 1833-1834. link> doi>
  • Ridyard CH, Whittaker RA, Higgins SD, Roberts SM, Willets AJ, Bailey PD, Rosair GM. 1996. Site selective oxidation of tricyclo[3.3.1.1(3,7)]decane (adamantane) and some of its derivatives using fungi of the genus Absidia. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1811-1819. link> doi>
  • Boyd CAR, Bronk JR, Lister N, Bailey PD. 1996. Stimulatory effect of glutamine on dipeptide transport by the rat small intestine, in vitro and in situ. JOURNAL OF PHYSIOLOGY-LONDON, vol. 493P, P104-P105. link>
  • Adams DR, Bailey PD, Collier ID, Leah SAH, Ridyard C. 1996. The mechanism for the rearrangement of the adamantyl cation. CHEMICAL COMMUNICATIONS, 333-334. link> doi>
  • TEMPLE C, BOYD C, BRONK J, BAILEY P. 1995. A COMPARISON OF THE UPTAKE KINETICS OF A NEUTRAL AND ANIONIC DIPEPTIDE INTO RAT RENAL-CORTEX BRUSH-BORBER MEMBRANE-VESICLES - EFFECT OF MEMBRANE-POTENTIAL AND PROTON GRADIENT. JOURNAL OF PHYSIOLOGY-LONDON, vol. 487P, P26-P27. link>
  • Lister N, Sykes AP, Bailey PD, Boyd CA, Bronk JR. 1995. Dipeptide transport and hydrolysis in isolated loops of rat small intestine: effects of stereospecificity. J Physiol, vol. 484 ( Pt 1), 173-182.
  • Sykes AP, Lister N, Bailey PD, Boyd CA, Bronk JR. 1995. Dipeptide transport and hydrolysis in rat small intestine, in vitro. Biochim Biophys Acta, vol. 1237(1), 70-76. doi>
  • BRONK J, LISTER N, BAILEY P, BOYD C. 1995. EFFECTS ON DIPEPTIDE TRANSPORT OF REDUCING THE PH IN THE LUMEN OF RAT SMALL-INTESTINE, IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, vol. 489P, P105. link>
  • BAILEY P. 1995. ON THE SELF-REPLICATION OF CHIRALITY. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1797-1798. link> doi>
  • TEMPLE C, BRONK J, BAILEY P, BOYD C. 1995. SUBSTRATE CHARGE DEPENDENCE OF STOICHIOMETRY SHOWS MEMBRANE-POTENTIAL IS THE DRIVING-FORCE FOR PROTON-PEPTIDE COTRANSPORT IN RAT RENAL-CORTEX. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, vol. 430(5), 825-829. link> doi>
  • BAHAJAJ A, BAILEY P, MOORE M, MORGAN K, VERNON J. 1994. ASYMMETRIC-SYNTHESIS OF SPIRO 2-PYRROLIDIN-5-ONES AND 2-PIPERIDIN-6-ONES. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 2511-2512. link> doi>
  • BAILEY P, MOORE M, MORGAN K, SMITH D, VERNON J. 1994. ENHANCING THE YIELD AND DIASTEREOSELECTIVITY OF THE PICTET-SPENGLER REACTION - A HIGHLY EFFICIENT ROUTE TO CIS-1,3-DISUBSTITUTED TETRAHYDRO-BETA-CARBOLINES. TETRAHEDRON LETTERS, vol. 35(21), 3587-3588. link> doi>
  • BAILEY P, LONDESBROUGH D, HANCOX T, HEFFERNAN J, HOLMES A. 1994. HIGHLY ENANTIOSELECTIVE SYNTHESIS OF PIPECOLIC ACID-DERIVATIVES VIA AN ASYMMETRIC AZA-DIELS-ALDER REACTION. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 2543-2544. link> doi>
  • BAILEY P, COLLIER I, HOLLINSHEAD S, MOORE M, MORGAN K, SMITH D, VERNON J. 1994. NEW ASYMMETRIC ROUTE TO BRIDGED INDOLE ALKALOIDS - FORMAL SYNTHESES OF (-)-SUAVEOLINE, (-)-RAUMACLINE AND (-)-N-B-METHYLRAUMACLINE. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1559-1560. link> doi>
  • BAILEY P, MORGAN K, SMITH D, VERNON J. 1994. NOVEL SPIRO CYCLIZATIONS OF N-ACYLIMINIUM IONS INVOLVING AN AROMATIC PI-NUCLEOPHILE. TETRAHEDRON LETTERS, vol. 35(38), 7115-7118. link> doi>
  • BAILEY P, HOLLINSHEAD S, MOORE M, MORGAN K, SMITHE D, VERNON J. 1994. STEREOSPECIFIC REDUCTION OF A BETA-KETO-NITRILE - FORMATION OF A SINGLE INDOLIC BETA-HYDROXY-NITRILE FROM A MIXTURE OF TAUTOMERS AND DIASTEREOISOMERS. TETRAHEDRON LETTERS, vol. 35(21), 3585-3586. link> doi>
  • BAILEY P. 1994. THE ART OF LECTURING. CHEMISTRY & INDUSTRY, 190. link>
  • Helliwell PA, Meredith D, Boyd CA, Bronk JR, Lister N, Bailey PD. 1994. Tripeptide transport in rat lung. Biochim Biophys Acta, vol. 1190(2), 430-434. doi>
  • BAILEY P, HOLLINSHEAD S, MCLAY N, EVERETT J, REYNOLDS C, WOOD S, GIORDANO F. 1993. AN ASYMMETRIC ROUTE TO THE DEMETHOXY-FUMITREMORGINS. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 451-458. link> doi>
  • BAILEY P, HOLLINSHEAD S, MCLAY N, MORGAN K, PALMER S, PRINCE S, REYNOLDS C, WOOD S. 1993. DIASTEREOSELECTIVITY AND ENANTIOSELECTIVITY IN THE PICTET-SPENGLER REACTION. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 431-439. link> doi>
  • BAILEY P and MCLAY N. 1993. USE OF THE KINETICALLY CONTROLLED PICTET-SPENGLER REACTION IN THE ASYMMETRIC-SYNTHESIS OF INDOLE ALKALOIDS - FORMAL SYNTHESES OF (-)-AJMALINE, (-)-KOUMINE, (-)-TABERPSYCHINE, (-)-KOUMIDINE AND (-)-SUAVOLINE. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 441-449. link> doi>
  • BAILEY P, CLARKE D, CROFTS G. 1992. SYNTHESIS AND STRUCTURE OF A NEW TYPE OF POLYCYCLIC PEPTIDE. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 658-660. link> doi>
  • BAILEY P and CROFTS G. 1992. SYNTHESIS OF A CYCLIC PEPTIDE POLYAMINE - A COMPARATIVE-STUDY OF ROUTES TO CYCLO-(LYS-LYS-GLY)2. TETRAHEDRON LETTERS, vol. 33(22), 3207-3210. link> doi>
  • BAILEY P, CARTER S, CLARKE D, CROFTS G, TYSZKA J, SMITH P, WARD P. 1992. SYNTHESIS OF DOUBLY CROSS-LINKED CYCLIC HEXAPEPTIDES. TETRAHEDRON LETTERS, vol. 33(22), 3211-3214. link> doi>
  • BAILEY P, CARTER S, CLARKE D, CROFTS G, SMITH P, WARD P. 1992. SYNTHESIS OF POLYCYCLIC HEXAPEPTIDES CONTAINING MULTIPLE INTRAMOLECULAR CROSS-LINKS. TETRAHEDRON LETTERS, vol. 33(22), 3215-3218. link> doi>
  • BAILEY P and MCLAY N. 1991. ASYMMETRIC-SYNTHESIS OF INDOLE ALKALOIDS FROM (L)-TRYPTOPHAN - FORMAL SYNTHESES OF (-)-KOUMINE, (-)-TABERPSYCHINE AND (-)-KOUMIDINE. TETRAHEDRON LETTERS, vol. 32(31), 3895-3898. link> doi>
  • BAILEY P, BROWN G, KORBER F, REED A, WILSON R. 1991. ASYMMETRIC-SYNTHESIS OF PIPECOLIC ACID-DERIVATIVES USING THE AZA-DIELS-ALDER REACTION. TETRAHEDRON-ASYMMETRY, vol. 2(12), 1263-1282. link> doi>
  • BAILEY P, WILSON R, BROWN G. 1991. ENANTIOSELECTIVE AND DIASTEREOSELECTIVE SYNTHESIS OF PIPECOLIC ACID-DERIVATIVES USING THE AZA-DIELS-ALDER REACTION OF IMINES WITH DIENES. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1337-1340. link> doi>
  • EVERETT J, REYNOLDS C, SPARKS C, PANGBORN W, BAILEY P, DAUTER Z, HELLIWELL M, HOLLINSHEAD S. 1990. CRYSTAL AND MOLECULAR-STRUCTURE OF A N(2)-BENZYL-1,3-DISUBSTITUTED-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE. JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, vol. 20(2), 109-115. link> doi>
  • DEANDEREZ D, HELLIWELL M, HABASH J, DODSON E, HELLIWELL J, BAILEY P, GAMMON R. 1989. A COMPARISON OF LAUE AND MONOCHROMATIC X-RAY ANALYSES OF A SMALL-MOLECULE CRYSTAL. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, vol. 45, 482-488. link>
  • BAILEY P, HOLLINSHEAD S, MCLAY N. 1989. A STEREOSELECTIVE ENTRY TO THE FUMITREMORGINS. TETRAHEDRON LETTERS, vol. 30(46), 6421-6422. link> doi>
  • BAILEY P and HARRISON M. 1989. ASYMMETRIC 3-AZA-COPE REARRANGEMENTS USING TICL4 CATALYSIS. TETRAHEDRON LETTERS, vol. 30(39), 5341-5344. link> doi>
  • BAILEY P, BOA A, CROFTS G, VANDIEPEN M, HELLIWELL M, GAMMON R, HARRISON M. 1989. ASYMMETRIC-SYNTHESIS OF PROTECTED ALPHA-FLUOROGLYCINES. TETRAHEDRON LETTERS, vol. 30(52), 7457-7460. link> doi>
  • BAILEY P, WILSON R, BROWN G. 1989. STEREOSELECTIVE SYNTHESIS OF PIPECOLIC ACID-DERIVATIVES USING AZA-DIELS-ALDER REACTIONS. TETRAHEDRON LETTERS, vol. 30(48), 6781-6784. link> doi>
  • EVERETT J, REYNOLDS C, SPARKS C, PANGBORN W, STRONG P, BAILEY P, DAUTER Z, HELLIWELL M, HOLLINSHEAD S. 1989. STRUCTURE OF DIMETHYL (1S,3S)-1-METHOXYCARBONYLMETHYL-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE-1,3-DICARBOXYLATE AT 165-K. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, vol. 45, 1805-1808. link> doi>
  • BAILEY P and HOLLINSHEAD S. 1988. APPLICATION OF A MODIFIED PICTET-SPENGLER REACTION TO THE SYNTHESIS OF OPTICALLY-ACTIVE TETRAHYDRO-BETA-CARBOLINES, KEY INTERMEDIATES IN THE PREPARATION OF MANY INDOLE ALKALOIDS. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 739-745. link> doi>
  • BAILEY P and BRYANS J. 1988. CHIRAL SYNTHESIS OF 5-HYDROXY-(L)-PIPECOLIC ACIDS FROM (L)-GLUTAMIC ACID. TETRAHEDRON LETTERS, vol. 29(18), 2231-2234. link> doi>
  • Montgomery GW, Jagger BA, Bailey PD. 1988. Normal cellular Ha ras p21 protein causes local disruption of bilayer phospholipid. Biochemistry, vol. 27(12), 4391-4395. doi>
  • BAILEY P. 1987. DIRECT PROOF OF THE INVOLVEMENT OF A SPIRO INTERMEDIATE IN THE PICTET-SPENGLER REACTION. JOURNAL OF CHEMICAL RESEARCH-S, 202-203. link>
  • BAILEY P, HOLLINSHEAD S, MCLAY N. 1987. EXCEPTIONAL STEREOCHEMICAL CONTROL IN THE PICTET-SPENGLER REACTION. TETRAHEDRON LETTERS, vol. 28(43), 5177-5180. link> doi>
  • BAILEY P. 1987. ON THE STEREOCHEMISTRY OF THE PICTET-SPENGLER REACTION. TETRAHEDRON LETTERS, vol. 28(43), 5181-5184. link> doi>
  • BAILEY P and HOLLINSHEAD S. 1987. SYNTHESIS OF 3-(INDOL-2-YL)-PROPENOATE DERIVATIVES OF TRYPTAMINE, VALUABLE INTERMEDIATES FOR THE PREPARATION OF INDOLE ALKALOIDS. TETRAHEDRON LETTERS, vol. 28(25), 2879-2882. link> doi>
  • BAILEY P and HOLLINSHEAD S. 1987. THE USE OF C-13 NMR IN THE DETERMINATION OF STEREOCHEMISTRY OF 1,2,3-TRISUBSTITUTED TETRAHYDRO-BETA-CARBOLINES. HETEROCYCLES, vol. 26(2), 389-399. link>
  • BAILEY P and HOLLINSHEAD S. 1985. ON THE ASSIGNMENT OF STEREOCHEMISTRY OF 1,3-DISUBSTITUTED TETRAHYDRO-BETA-CARBOLINES USING C-13 NMR-SPECTROSCOPY. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1575-1576. link> doi>
  • BAILEY P, HOLLINSHEAD S, DAUTER Z. 1985. THE FORMATION OF OPTICALLY-ACTIVE 1,3-DISUBSTITUTED AND 1,1,3-TRISUBSTITUTED TETRAHYDRO-BETA-CARBOLINES USING A MODIFIED PICTET-SPENGLER REACTION. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1507-1509. link> doi>

Chapters

  • Baldwin JE, Bailey PD, Gallacher G, Singleton KA, Wallace PM. 2005. Amides. In Comprehensive Organic Functional Group Transformations II. Katritzky AR and Taylor RJK (Eds.). (vol. 5). Elsevier.
  • Bailey PD. 2003. A communication course for chemists. In A Handbook for Research & Learning in Higher Education: Enhancing Academic Practice. Fry H, Ketteridge S, Marshall S (Eds.). (2nd ed.). Kogan Page.

Other

  • Foley DW, Bailey PD, Price RA, Meredith D, Pettecrew R. 2008. Improving drug oral bioavailability by targeting PepT1. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (vol. 236). link>
  • Bailey PD. 2008. Should 'teacher centred teaching' replace 'student centred learning'?. CHEMISTRY EDUCATION RESEARCH AND PRACTICE (vol. 9, pp. 70-74). link> doi>