Dr Katherine J. Haxton

Title: Senior Lecturer in Chemistry
Phone: (+44) 01782 7 34209
Email:
Location: Lennard-Jones 1.43
Role: Programme Director for Chemistry and Medicinal Chemistry
Contacting me: Office Hours TBC
Otherwise please email to arrange an appointment or pop past if my door is open.
Katherine Haxton

I was appointed as a Lecturer in Chemistry at Keele in April 2008 and Senior Lecturer in April 2015.  I obtained my MChem degree in 2001 from the University of St Andrews and remained there for my PhD (2004) under the supervision of Prof. Russell Morris, thesis “Silsesquioxane Dendrimers as Catalysts: Synthesis and Molecular Modelling”.  I then moved to the University of British Columbia, Vancouver, Canada as a Postdoctoral Research Fellow in Pharmaceutical Sciences, and in 2006 was awarded a CIHR-RxD Postdoctoral Research Fellowship in Pharmacy working on “Dendrimers and Hyperbranched Polymers for the Delivery of Organometallic Anticancer Drugs”.

molecule My research falls into the broad field of materials chemistry, specifically the interactions between metal ions and dendrimers or hyperbranched polymers.  These systems are useful for environmental applications like the remediation of heavy metal pollution from ground water, or medicinal applications involving the use of biodegradable polymers to deliver organometallic anticancer drugs such as cisplatin.   I am particularly interested in the synthesis of new dendrimers and hyperbranched polymers with polyhedral oligomeric silsesquioxane (POSS) cores.  These are cubic molecules with corner silicon atoms and bridging oxygen atoms to which 8 branches can be attached, leading to a higher density of terminal and internal ligand groups in fewer reactive steps. We are currently working on various projects using POSS molecules including creation of dendrimers through thiol-ene click chemistry and MOFS using POSS building blocks.

I am also very interested in the attitudes held by the public towards chemistry and am currently running projects on 'chemophobia' - the irrational fear of chemistry. Through mixed methods including questionnaires and focus groups, we aim to determine the complex mix of attitudes surrounding chemophobia and ultimately hope to devise outreach interventions to tackle some of them.

For further information see : www.kjhaxton.com

Selected Publications

  • Haxton KJ and Burt HM. 2009. Polymeric drug delivery of platinum-based anticancer agents. J Pharm Sci, vol. 98(7), 2299-2316. link> doi>
  • Haxton KJ and Morris RE. 2009. Polyhedral Oligomeric Silsesquioxane Dendrimers. In Silicon-Containing Dendritic Polymers. Dvornic PR and Owen MJ (Eds.). (vol. 2). Springer Verlag. doi>
  • Haxton KJ and Burt HM. 2008. Hyperbranched polymers for controlled release of cisplatin. Dalton Trans, 5872-5875. link> doi>
  • Zhang XJ, Haxton KJ, Ropartz L, Cole-Hamilton DJ, Morris RE. 2001. Synthesis and computer modelling of hydroxy-derivatised carbosilane dendrimers based on polyhedral silsesquioxane cores. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 3261-3268. link> doi>
  • Fisher N, Hilton-Bolt T, Edwards MG, Haxton KJ, McKenzie M, Allin SM, Richardson A. 2014. Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS, vol. 5(1), 34-39. link> doi>

Full Publications List show

Journal Articles

  • Fisher N, Hilton-Bolt T, Edwards MG, Haxton KJ, McKenzie M, Allin SM, Richardson A. 2014. Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS, vol. 5(1), 34-39. link> doi>
  • Haxton KJ and McGarvey DJ. 2011. Screencasting as a means of providing timely, general feedback on assessment. 18-21. doi>
  • Haxton KJ and Burt HM. 2009. Polymeric drug delivery of platinum-based anticancer agents. J Pharm Sci, vol. 98(7), 2299-2316. link> doi>
  • Haxton KJ and Burt HM. 2008. Hyperbranched polymers for controlled release of cisplatin. Dalton Trans, 5872-5875. link> doi>
  • Haxton KJ, Cole-Hamilton DJ, Morris RE. 2007. Silsesquioxane dendrimers as catalysts: a bite-sized molecular dynamics study. Dalton Trans, 3415-3420. link> doi>
  • Haxton KJ, Cole-Hamilton DJ, Morris RE. 2004. The structure of phosphine-functionalised silsesquioxane-based dendrimers: a molecular dynamics study. Dalton Trans, 1665-1669. link> doi>
  • Ropartz L, Haxton KJ, Foster DF, Morris RE, Slawin AMZ, Cole-Hamilton DJ. 2002. Phosphine containing dendrimers for highly regioselective rhodium catalysed hydroformylation of alkenes: a positive 'dendritic effect'. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 4323-4334. link> doi>
  • Zhang XJ, Haxton KJ, Ropartz L, Cole-Hamilton DJ, Morris RE. 2001. Synthesis and computer modelling of hydroxy-derivatised carbosilane dendrimers based on polyhedral silsesquioxane cores. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 3261-3268. link> doi>
  • Haxton KJ and McGarvey DJ. Using Audio for Feedback on Assessments: Tutor and Student Experiences. New Directions in the Teaching of Physical Sciences, 5-9.

Chapters

  • Haxton KJ and Morris RE. 2009. Polyhedral Oligomeric Silsesquioxane Dendrimers. In Silicon-Containing Dendritic Polymers. Dvornic PR and Owen MJ (Eds.). (vol. 2). Springer Verlag. doi>

Other

  • Haxton KJ. 2011. All about arsenic. doi>
  • Haxton KJ. Chemical counselling.
  • haxton KJ. Peer and simple?. link>
  • haxton KJ. Peer and simple?. link>
  • Haxton KJ. Talking Chemical/Diagnosis Progress. Keele University. link>
  • Haxton KJ. Teaching with microscale reactions. link>
  • Haxton KJ. Teaching with microscale reactions. link>
  • Haxton KJ. What does the word chemical mean to you?. link>

I currently teach on the following modules:

First Year:

Semester 1

CHE-10047 Chemical Concepts and Structure

CHE-10048 Practical and Professional Chemistry Skills 1

Semester 2

CHE-10049 Practical and Professional Chemistry Skills 2

CHE-10050 Chemical Properties and Reactions 

CHE-10051 Sustainable Chemistry (Module Leader)

CHE-10054 Sustainable Chemistry (NXU) (Module Leader)

Second Year:

Semester 1

CHE-20030 Spectroscopy and Analytical Chemistry 

CHE-20037 Industrial Chemistry (Module Leader)

Semester 2

CHE-20031 Structural Inorganic Chemistry (Module Leader)

CHE-20032 Sustainable Chemistry (Module Leader)

Third Year:

Semester 1

CHE-30038 Chemical Kinetics, Photochemistry and Inorganic Reaction Mechanisms

Full Year

CHE-30002 Dual Honours Research Project

CHE-30040 Chemistry Research Project

CHE-30041 Medicinal Chemistry Research Project

I run a variety of outreach activities include a 'Science of Slime' workshop, 'Science of Minions' lecture and other activities in collaboration with Keele University, the North Staffordshire local section of the Royal Society of Chemistry and the Salters' Institute.