Dr Katherine J. Haxton

Title: Lecturer in Chemistry
Phone: (+44) 01782 7 34209
Email:
Location: Lennard-Jones 1.43
Role: Course Director
Contacting me: Try my office or make an appointment by email
Haxton_Katherine

I was appointed as a Lecturer in Chemistry at Keele in April 2008.  I obtained my MChem degree in 2001 from the University of St Andrews and remained there for my PhD (2004) under the supervision of Prof. Russell Morris, thesis “Silsesquioxane Dendrimers as Catalysts: Synthesis and Molecular Modelling”.  I then moved to the University of British Columbia, Vancouver, Canada as a Postdoctoral Research Fellow in Pharmaceutical Sciences, and in 2006 was awarded a CIHR-RxD Postdoctoral Research Fellowship in Pharmacy working on “Dendrimers and Hyperbranched Polymers for the Delivery of Organometallic Anticancer Drugs”.

molecule My research falls into the broad field of materials chemistry, specifically the interactions between metal ions and dendrimers or hyperbranched polymers.  These systems are useful for environmental applications like the remediation of heavy metal pollution from ground water, or medicinal applications involving the use of biodegradable polymers to deliver organometallic anticancer drugs such as cisplatin.   I am particularly interested in the synthesis of new dendrimers and hyperbranched polymers with polyhedral oligomeric silsesquioxane cores.  These are cubic molecules with corner silicon atoms and bridging oxygen atoms to which 8 branches can be attached, leading to a higher density of terminal and internal ligand groups in fewer reactive steps.

For further information see : www.kjhaxton.com

Selected Publications

  • Haxton KJ and Burt HM. 2009. Polymeric drug delivery of platinum-based anticancer agents. J Pharm Sci, vol. 98(7), 2299-2316. link> doi>
  • Haxton KJ and Morris RE. 2009. Polyhedral Oligomeric Silsesquioxane Dendrimers. In Silicon-Containing Dendritic Polymers. Dvornic PR and Owen MJ (Eds.). (vol. 2). Springer Verlag. doi>
  • Haxton KJ and Burt HM. 2008. Hyperbranched polymers for controlled release of cisplatin. Dalton Trans, 5872-5875. link> doi>
  • Zhang XJ, Haxton KJ, Ropartz L, Cole-Hamilton DJ, Morris RE. 2001. Synthesis and computer modelling of hydroxy-derivatised carbosilane dendrimers based on polyhedral silsesquioxane cores. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 3261-3268. link> doi>
  • Haxton KJ. 2011. All about arsenic. doi>

Full Publications List show

Journal Articles

  • Haxton KJ and Burt HM. 2009. Polymeric drug delivery of platinum-based anticancer agents. J Pharm Sci, vol. 98(7), 2299-2316. link> doi>
  • Haxton KJ and Burt HM. 2008. Hyperbranched polymers for controlled release of cisplatin. Dalton Trans, 5872-5875. link> doi>
  • Haxton KJ, Cole-Hamilton DJ, Morris RE. 2007. Silsesquioxane dendrimers as catalysts: a bite-sized molecular dynamics study. Dalton Trans, 3415-3420. link> doi>
  • Haxton KJ, Cole-Hamilton DJ, Morris RE. 2004. The structure of phosphine-functionalised silsesquioxane-based dendrimers: a molecular dynamics study. Dalton Trans, 1665-1669. link> doi>
  • Ropartz L, Haxton KJ, Foster DF, Morris RE, Slawin AMZ, Cole-Hamilton DJ. 2002. Phosphine containing dendrimers for highly regioselective rhodium catalysed hydroformylation of alkenes: a positive 'dendritic effect'. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 4323-4334. link> doi>
  • Zhang XJ, Haxton KJ, Ropartz L, Cole-Hamilton DJ, Morris RE. 2001. Synthesis and computer modelling of hydroxy-derivatised carbosilane dendrimers based on polyhedral silsesquioxane cores. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 3261-3268. link> doi>
  • Haxton KJ and McGarvey DJ. Screencasting as a means of providing timely, general feedback on assessment. 18-21.
  • Haxton KJ and McGarvey DJ. Using Audio for Feedback on Assessments: Tutor and Student Experiences. New Directions in the Teaching of Physical Sciences, 5-9.

Chapters

  • Haxton KJ and Morris RE. 2009. Polyhedral Oligomeric Silsesquioxane Dendrimers. In Silicon-Containing Dendritic Polymers. Dvornic PR and Owen MJ (Eds.). (vol. 2). Springer Verlag. doi>

Other

  • Haxton KJ. 2011. All about arsenic. doi>
  • Haxton KJ. Chemical counselling.

I currently teach on the following modules:

CHE-10047 Chemical Concepts and Structure

CHE-10048 Practical and Professional Chemistry Skills 1

CHE-10049 Practical and Professional Chemistry Skills 2

CHE-10050 Chemical Properties and Reactions (Module Leader)

CHE-20002 Spectroscopic Methods (Module Leader)

CHE-20020 Organometallic Chemistry and the f Block

CHE-30002 Dual Honours Research Project

CHE-30030 Single Honours Research Project

CHE-30009 Research Topics in Biological and Medicinal Chemistry