Chemistry
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- 2008-2009
Seminar Series 2008-2009
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2008 |
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| Sept 17th | Dr Graeme M. Day Department of Chemistry, University of Cambridge |
Are Crystal Structure Predictable? A Challenge for Computational Chemistry.
As the methods are further improved, and they become more generally applicable, the possibility of applying such calculations to the design of new materials with desired properties is becoming a reality. The presentation will describe recent developments and assessment of methods being developed for crystal structure prediction of organic molecules.
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| Oct 1st | Ms. Lina Meghani Keele University |
Towards new functional porous polymeric materials. |
| Ms. Sarah Sherratt Keele University |
Ferromagnetic resonance as a tool for characterising metal oxides. | |
| Oct 10th | Mr. James Beardmore Keele University |
Towards a model of non-equilibrium binding of metal ions in biological systems. |
| Ms. Laura Sunderland Keele University |
Bioactive compounds derived from Verona oil. | |
| Oct 29th | Dr. Chris Solomon School of Physical Sciences, University of Kent |
"Making Faces" - Statistical and evolutionary techniques for the synthesis of human faces.
Download PDF version of Abstract We will discuss the scientific basis of our system which exploits a number of well-known techniques, demonstrate how it works and present results of both laboratory and real-world use. |
| Nov 12th | Dr. Dave Adams Department of Chemistry, University of Liverpool |
The self-assembly of peptides and polymers in novel materials.
The formation of hydrogels through the self-assembly of oligopeptides is receiving considerable attention because of their potential usefulness as novel structurants. There are relatively few studies of the structure-property relationships in terms of the chemical character of the gelator used. Recently, the gelation behaviour of dipeptides coupled to a fluorenylmethoxycarbonyl (Fmoc) moiety has been reported. These materials can be gelled using a pH trigger, such that the soluble sodium salt of the Fmoc-dipeptide is converted to the acid form (which gels) by a drop in pH. These materials represent an interesting opportunity to examine the effect of altering a single amino acid on the properties of the final gel. We show that the gel strength of the hydrogels formed from Fmoc-dipeptides is determined by the constituent amino acids, with the final gel strength linked to the overall hydrophobicity of the Fmoc-dipeptide. Gelation was triggered using glucono-d-lactone, which hydrolyses in water controllably lowering the pH. This allows hydrogels with pre-determined properties to be designed. Lowering the pH using this method allows the development of the gel strength and the microstructure of the networks to be followed by a number of techniques including cryo-SEM, CD and rheology, giving insight into the mechanism of gel formation. |
| Nov 29th | Dr. Karl Hemming School of Applied Sciences, University of Huddersfield |
From lowly bacteria to outer space: efforts in the synthesis of nitrogen containing natural products.
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Dec 3rd
Note: at 3pm! |
Dr. Susanna Texeira
Keele University and Institut Laue-Langevin, Grenoble |
Neutron crystallography at high, medium and low resolution. |
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Dec 10th
4pm
LJ1.75 |
Prof. John Wallis School of Science and Technology, Nottingham Trent University |
Recent Progress in the Synthesis of Functionalised Organosulfur Donors, and the Study of Molecular Interactions.
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2009 |
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Jan 14th
postponed! |
Prof. Matt Rosseinsky Department of Chemistry, University of Liverpool |
Recent advances in inorganic functional materials.
Please note that this seminar has been postponed until June 24th! |
| Jan 28th | Liz Maddock, Keele University |
Computer modelling of intrinsic defects and rare earth doping in KYF4, K2YF5 and KY3F10. |
| Dr. David Foley Keele University |
Improving the oral bioavailability of drugs by targeting PepT1 mediated transport. | |
| Feb 11th | Dr. Katherine Haxton Keele University |
Can science blogging enhance your research life? |
| Dr. Jane Essex Keele University Education, School of Public Policy and Professional Practice |
A cognitive framework for novice chemists. | |
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Feb 25th
Note: at 1 pm!
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Dr. Richard Hamlyn Xention Ltd. |
Modern strategies in drug discovery. Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice and is gaining in clinical importance as the population ages. The treatment of AF is, however, controversial and often problematic. Although a number of drugs and therapeutic approaches are used for the management of AF, each has significant side effects and none is suitable for the prevention of the disease. This lecture will explore the process of modern drug discovery and highlight those areas in which new developments in technology have aided in the design of potential lead compounds. |
| March 4th | Prof. Malcolm Stevens The University of Nottingham |
'Chemical whispering: an approach to the discovery of novel antitumour agents'
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| March 18th |
Mr. John Butcher |
Computational Intelligence: A concrete field. |
| Mr. Dave Thompson Keele University |
Elemental tagging for bioanalysis, with ICPMS detection. | |
| March 25th | Ms. Tess Phillips Keele University |
Towards the total synthesis of (+)-ajmaline. |
| Mr. Mark Beard Keele University |
Exploring cis-selective Pictet Spengler reactions in the total synthesis of indole alkaloids. | |
| April 22nd | Dr. Grahame McKenzie
Hull University |
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| May 6th | Dr. Tony Edge Astra Zeneca |
High Temperature HPLC - a hot topic for LC and LC-MS. |
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May 13th
postponed! |
Prof. Matt Rosseinsky Department of Chemistry, University of Liverpool |
Recent advances in inorganic functional materials.
Please note that this seminar has been postponed to 24th of June! |
| May 27th |
Ms. Hannah Moore Keele University |
Usefulness of Hydrocarbons within Forensic Entomology in establishing the Postmortem Interval (PMI). |
| June 10th | Prof Alan R. Katritzky University of Florida |
Peptide and Peptide Conjugates.
Alan Katritzky was born in London, U.K. and educated at St. Catherine’s College, Oxford, of which he became an Honorary Fellow in 2006. He was a Founder Fellow of Churchill College, Cambridge, and then founding Professor/Dean of the School of Chemical Sciences at the University of East Anglia, before crossing the Atlantic in 1980 to become Kenan Professor and Director of The Center for Heterocyclic Compounds at the University of Florida. He has researched, published, lectured, and consulted widely in heterocyclic chemistry, synthetic methods, and QSPR. He created the non-for-profit foundation ARKAT and since 2000 has organized the annual ‘‘Florida Heterocyclic and Synthetic Conferences’’ (Flohet), and publishes the ‘‘Archive for Organic Chemistry’’ (Arkivoc) completely free on the Internet at arkat-usa.org. His honours from 20 countries include 14 honorary doctorates. |
| June 24th | Prof. Matt Rosseinsky DPhil, FRSC, FRS Department of Chemistry, University of Liverpool |
New chemistry of oxides and nanoporous materials.
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Given the chemical diagram of a molecule, is it possible to predict how it will crystallise (i.e. space group, unit cell parameters and all atomic coordinates)? The development of computational methods to address this problem has been a great challenge for computational chemistry over the past few decades and some methods are now starting to produce reliable predictions for simple systems.
This lecture will have something for everyone - from the general scientist to the specialist synthetic chemist. The talk will start with an exploration of the world of alchemy and the search for the philosophers' stone, taking us via a few murders and spontaneous human combustion, before moving on to a general introduction to some phosphorus based methodology in organic synthesis. The talk will then look at microbial and extraterrestrial sources of molecules that are of interest to some of the projects that we are involved with at Huddersfield, with a focus on nitrogen containing natural products of biological interest such as the antitumour jenamidines, the potent toxin anatoxin-a, and the antitumour antibiotic anthramycins.
BEDT-TTF 1 has provided a wide range of radical cation salts which show a variety of electrical properties. Here the synthetic approaches to the preparation of functionalised derivatives of BEDT-TTF and related ring systems will be presented including, in particular, chiral donors such as 2-4 and donors with metal binding groups such as 5. Preliminary results from electrocrystallisation and charge transfer salt formation will discussed. The use of donor 5 to provide a molecular capsule will be illustrated. There will be a short discussion of progress on another project concerning the study of attractive intermolecular interactions.
The talk will give illustrations, from own experiences, of a cost-effective method to develop novel chemical entities with unique pharmacophores, novel biological properties, and with robust pharmaceutical properties without synthesising and screening zillions of compounds.
Pollen shells are tough customers but could be harmless and useful.
Metal oxides and nanoporous materials have a wide range of technological applications. This talk will address the synthesis of new metal oxides with applications as ionic and mixed conductors in solid oxide fuel cells, and the use of molecule-based nanoporous materials as reaction containers for the observation of chemical transformations. Open-framework materials families based on amino acids will be presented.
