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PHA-30033 - Module Specification
School of Pharmacy and Bioengineering
Faculty of Medicine & Health Sciences

For academic year: 2023/24 Last Updated: 13 February 2024

PHA-30033 - Precision Medicine
Coordinator: Gianpiero Di Leva Tel: +44 1782 671651
Lecture Time: See Timetable...
Level: Level 6
Credits: 30
Study Hours: 300
School Office:

Programme/Approved Electives for 2023/24

None

Available as a Free Standing Elective

No

Co-requisites

None

Prerequisites

None

Barred Combinations

None

Description for 2023/24

Understanding how your genome sequence is different from other individuals and has an impact on gene expression, predisposition to diseases and response to therapies is the core principle of Precision Medicine. Today, due to the reduction in costs of genotyping and increasing availability of multi-omics technologies, this has become a reality. The key aim of this module is to allow you to explore and build understanding in multi-omics technologies and how they can be applied in healthcare to provide precision medicine.

Aims
This module will introduce students to the concept of personalised/precision medicine, the application of precision medicine in medicine e.g cancer and orthopaedics and to introduce students to multi-omics technologies, their principle and applications.

Intended Learning Outcomes

Critically discuss the principles of Precision Medicine and debate how multi-omics technologies can contribute to the development of a patient-tailored treatment.: 1,2,3
Explore the applications and critically compare the limitations of a range of multi-omics technologies.: 1,2,3
Exemplify an understanding of the bioinformatics tools required for the analysis of omics data and critically discuss their applications e.g. pathway analysis and RNA-sequencing data analysis.: 1,2,3

Study hours

Lectures (22 hrs)
Monographic Course (18 hrs)
Journal Clubs (12 hrs)
Laboratory Demonstration and Case Study (10 hrs)
Presentation - Online Drop-in sessions (10 hrs)
Poster Presentation Sessions (5 hrs)
Assignment Formative Feedback Online Drop-in Sessions (10 hrs)
Independent Studies (213 hrs)
- Pre-reading/reviewing module content (43 hrs)
- Preparation for journal clubs (30 hrs)
- Module assignments (100 hrs)
- Independent/Additional Reading (40 hrs)

School Rules

None

Description of Module Assessment

1: Poster Presentation weighted 40%
Poster Presentation
A poster presentation on an `omics technology, how it works and how it has been/or could be used for a clinical/trial application. Each poster presentation will last 10 minutes with 5 minutes Q&A session with academics. The quality of the poster would be worth 60% and the delivery and ability to answer questions worth 40%.

2: Essay-Plan weighted 5%
Mind Map
A mind-map to develop an approach for stratifying patients for treatment of a disease of choice or for stratifying patients into sub-categories of a disease of choice. They should consider how genetic and/or environmental factors may contribute to prognosis or therapeutic outcome and what tools/techniques ('omics and biomarkers) can be used to identify whether these genetic and environmental differences exist between patients. This will provide formative feedback for assessment 3.

3: Essay weighted 55%
Written Assignment
A 2500 word written assignment to develop an approach for stratifying patients for treatment of a disease of choice or for stratifying patients into sub-categories of a disease of choice. They should consider how genetic and/or environmental factors may contribute to prognosis or therapeutic outcome and what tools/techniques ('omics and biomarkers) can be used to identify whether these genetic and environmental differences exist between patients.

Please note that for the 2022/23 Academic Year programmes may be adapted to operate in accordance with a flexible, digital approach. This means that there may be some changes made to how modules are delivered and assessed. The latest information will be provided to you by your School in module handbooks. We endeavour to give you as much notice as possible of any changes and details about the circumstance in which changes are made to programmes can be found in the Student Agreement, available at: https://www.keele.ac.uk/student-terms-and-conditions/

Last Updated: 13 February 2024